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Actual physical dependence on a prescribed medication will not signify dependancy. Actual physical dependence consists of the occurrence of a withdrawal syndrome when There may be sudden reduction or cessation in drug use or if an opiate antagonist is administered. Actual physical dependence could be detected following a few days of opioid therapy.

Acetaminophen is metabolized in the liver through cytochrome P450 microsomal enzyme. About 8085% of the acetaminophen in the human body is conjugated principally with glucuronic acid also to a lesser extent with sulfuric acid and cysteine. After hepatic conjugation, 90 to 100% of the drug is recovered while in the urine with in the first day.Vigoro